A model of arterial plaque cap development and degradation

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Venue:DM 194

Thursday, March 24, 4—5pm, DM 194,

Professor Jon Bell, U Maryland, Baltimore County

Title: A model of arterial plaque cap development and degradation

Abstract: Cardiovascular disease is a leading cause of death in the US, and a common form of cardiovascular disease is atherosclerosis. This is an inflammatory disease of the large and medium arteries due to plaques that develop in the arterial wall. In modeling development of a lesion in an artery wall, there are a number of chemotactic mechanisms going on within the wall layer that lead to an arterial plaque with fibrous cap. We introduce a model involving some of these dynamic processes, prove some theoretical results, do some simulations, and examine the implications of the model results. Our main goal of the project is to isolate potential mechanisms that lead to plaque rupture through thinning of the fibrous cap.